Interleukin-2 production by human fetal lymphocytes.
J Reprod Immunol
; 14(3): 247-55, 1988 Dec.
Article
em En
| MEDLINE
| ID: mdl-3265729
ABSTRACT
IL-2 production by PHA-stimulated human lymphocytes in umbilical blood was studied ontogenetically. Lymphocytes from the 16-week-old fetus produced appreciable amounts of interleukin-2 (IL-2). In 16- to 36-week-old fetuses the IL-2 production rate was found to be significantly higher than that in adults. When signal transduction, which is mediated by high affinity IL-2 receptors (IL-2R), was studied after adding exogenous IL-2 to PHA-blast lymphocytes, the response of the 24-week-old fetus was similar to that of adults. These results indicate that the attainment of IL-2 production and the function of IL-2 receptors are completed at a relatively early stage of fetal development.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Interleucina-2
/
Sangue Fetal
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Japão