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Inhibition of IRAK4 kinase activity improves ethanol-induced liver injury in mice.
Wang, Han; Zhou, Hao; Zhang, Quanri; Poulsen, Kyle L; Taylor, Vanessa; McMullen, Megan R; Czarnecki, Doug; Dasarathy, Dhweeja; Yu, Minjia; Liao, Yun; Allende, Daniela S; Chen, Xing; Hong, Lingzi; Zhao, Junjie; Yang, Jinbo; Nagy, Laura E; Li, Xiaoxia.
Afiliação
  • Wang H; School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Northern Ohio Alcohol Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Zhou H; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Northern Ohio Alcohol Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Zhang Q; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Northern Ohio Alcohol Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Poulsen KL; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Northern Ohio Alcohol Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Taylor V; Rigel Pharmaceuticals, South San Francisco, CA 94080, USA.
  • McMullen MR; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Northern Ohio Alcohol Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Czarnecki D; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Northern Ohio Alcohol Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Dasarathy D; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Harvard University, Massachusetts Hall, Cambridge, MA 02138, USA.
  • Yu M; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA, 02138, USA.
  • Liao Y; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Allende DS; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Pathology Department, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Chen X; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Hong L; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Zhao J; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Yang J; School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China. Electronic address: yangjb@lzu.edu.cn.
  • Nagy LE; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Northern Ohio Alcohol Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: nagyl3@ccf.org.
  • Li X; Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Northern Ohio Alcohol Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: lix@ccf.org.
J Hepatol ; 73(6): 1470-1481, 2020 12.
Article em En | MEDLINE | ID: mdl-32682051
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinases Associadas a Receptores de Interleucina-1 / Doença Hepática Induzida por Substâncias e Drogas / Inibidores de Checkpoint Imunológico / Hepatopatias Alcoólicas Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinases Associadas a Receptores de Interleucina-1 / Doença Hepática Induzida por Substâncias e Drogas / Inibidores de Checkpoint Imunológico / Hepatopatias Alcoólicas Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos