Engineering carboxylic acid reductase for selective synthesis of medium-chain fatty alcohols in yeast.

Hu, Yating; Zhu, Zhiwei; Gradischnig, David; Winkler, Margit; Nielsen, Jens; Siewers, Verena

Hu, Yating; Zhu, Zhiwei; Gradischnig, David; Winkler, Margit; Nielsen, Jens; Siewers, Verena.

Afiliação

Hu Y; Department of Biology and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
Zhu Z; Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
Gradischnig D; Department of Biology and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
Winkler M; Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
Nielsen J; School of Bioengineering, Dalian University of Technology, 116024 Dalian, China.
Siewers V; Institute of Molecular Biotechnology, Graz University of Technology, A-8010 Graz, Austria.

Proc Natl Acad Sci U S A ; 117(37): 22974-22983, 2020 09 15.

Article em En | MEDLINE | ID: mdl-32873649

Assuntos

Álcoois Graxos/metabolismo; Oxirredutases/metabolismo; Antiporters/metabolismo; Biocombustíveis; Ácidos Graxos/metabolismo; Engenharia Metabólica/métodos; Proteínas de Transporte de Cátions Orgânicos/genética; Oxirredutases/fisiologia; Engenharia de Proteínas/métodos; Saccharomyces cerevisiae/metabolismo; Proteínas de Saccharomyces cerevisiae/metabolismo

Palavras-chave

Saccharomyces cerevisiae; carboxylic acid reductase; high-throughput screening; medium-chain fatty alcohols; protein engineering

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredutases / Álcoois Graxos Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suécia

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