Genome sequence of segmented filamentous bacteria present in the human intestine.
Commun Biol
; 3(1): 485, 2020 09 04.
Article
em En
| MEDLINE
| ID: mdl-32887924
ABSTRACT
Segmented filamentous bacteria (SFB) are unique immune modulatory bacteria colonizing the small intestine of a variety of animals in a host-specific manner. SFB exhibit filamentous growth and attach to the host's intestinal epithelium, offering a physical route of interaction. SFB affect functions of the host immune system, among them IgA production and T-cell maturation. Until now, no human-specific SFB genome has been reported. Here, we report the metagenomic reconstruction of an SFB genome from a human ileostomy sample. Phylogenomic analysis clusters the genome with SFB genomes from mouse, rat and turkey, but the genome is genetically distinct, displaying 65-71% average amino acid identity to the others. By screening human faecal metagenomic datasets, we identified individuals carrying sequences identical to the new SFB genome. We thus conclude that a unique SFB variant exists in humans and foresee a renewed interest in the elucidation of SFB functionality in this environment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Genoma Bacteriano
/
Intestinos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Suécia