Patient-derived malignant pleural mesothelioma cell cultures: a tool to advance biomarker-driven treatments.
Thorax
; 75(11): 1004-1008, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32943495
ABSTRACT
Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived MPM cell cultures (n=16) exhibited stemness features and reflected intratumour and interpatient heterogeneity. A subset of the cells were subjected to high-throughput drug screening and coculture assays with cancer-specific cytotoxic T cells and showed diverse responses. Some of the biphasic MPM cells were capable of processing and presenting the neoantigen SSX-2 endogenously. In conclusion, patient-derived MPM cell cultures are a promising and faithful ex vivo model of MPM.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pleurais
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Células Tumorais Cultivadas
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Biomarcadores Tumorais
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Mesotelioma Maligno
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido