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Urinary podocyte-derived microparticles in youth with type 1 and type 2 diabetes.
Sullivan, Katie M; Scholey, James; Moineddin, Rahim; Sochett, Etienne; Wicklow, Brandy; Elia, Yesmino; Xiao, Feng; Mederios, Thalia; Sadi, Pusha; Burger, Dylan; Mahmud, Farid H; Dart, Alison B.
Afiliação
  • Sullivan KM; Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. KatieMarie.Sullivan@pennmedicine.upenn.edu.
  • Scholey J; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. KatieMarie.Sullivan@pennmedicine.upenn.edu.
  • Moineddin R; Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Sochett E; University Health Network, University of Toronto, Toronto, ON, Canada.
  • Wicklow B; Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada.
  • Elia Y; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Xiao F; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
  • Mederios T; Diabetes Research Envisioned and Accomplished in Manitoba (DREAM), Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
  • Sadi P; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Burger D; Kidney Research Centre, Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
  • Mahmud FH; Kidney Research Centre, Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
  • Dart AB; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Diabetologia ; 64(2): 469-475, 2021 02.
Article em En | MEDLINE | ID: mdl-33037887
ABSTRACT
AIMS/

HYPOTHESIS:

The release of podocyte-derived microparticles into the urine may reflect early kidney injury in diabetes. We measured the urinary excretion of podocyte-derived microparticles in youth with type 1 and type 2 diabetes, and related the values to blood pressure, renal function and blood glucose levels.

METHODS:

Cross-sectional, exploratory analysis of urine samples and clinical data from youth with type 1 (n = 53) and type 2 (n = 50) diabetes was carried out. Urinary podocyte-derived microparticle numbers, measured by flow cytometry, were assessed in relation to measures of blood glucose levels and renal function.

RESULTS:

Podocyte-derived microparticle excretion (MPE) normalised to urinary creatinine (MP/UCr) was higher in type 1 vs type 2 diabetes (median [IQR] MP/UCr 7.88 [8.97] vs 1.84 [8.62]; p < 0.0001), despite the type 2 diabetes group having higher blood pressure (systolic blood pressure, median [range] 124 [110-154] vs 114 [94-143] mmHg) and higher proportions of microalbuminuria (44.0% vs 13.2%), but shorter time since diabetes diagnosis (median [range] 1.2 [0.0-7.0] vs 6.4 [2.0-13.9] years), than the type 1 diabetes cohort. MPE in youth with type 1 diabetes was associated with blood glucose (p = 0.01) and eGFR (p = 0.03) but not HbA1c, systolic or diastolic blood pressure or urine albumin/creatinine ratio. After adjustment for age at baseline, duration of diabetes, sex and BMI, the association with eGFR remained significant (p = 0.04). No associations were found between MPE and these clinical variables in youth with type 2 diabetes. CONCLUSIONS/

INTERPRETATION:

Significant associations between podocyte MPE, blood glucose levels and eGFR were observed in youth with type 1 diabetes but not in those with type 2 diabetes, notwithstanding increased renal pathology in the type 2 diabetes cohort. These findings suggest that podocyte injury differs in the two diabetes cohorts. Graphical abstract.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicemia / Diabetes Mellitus Tipo 1 / Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas / Podócitos / Micropartículas Derivadas de Células / Injúria Renal Aguda Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicemia / Diabetes Mellitus Tipo 1 / Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas / Podócitos / Micropartículas Derivadas de Células / Injúria Renal Aguda Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos