Small-Molecule Antibiotics Inhibiting tRNA-Regulated Gene Expression Is a Viable Strategy for Targeting Gram-Positive Bacteria.

Väre, Ville Y P; Schneider, Ryan F; Kim, Haein; Lasek-Nesselquist, Erica; McDonough, Kathleen A; Agris, Paul F

Väre, Ville Y P; Schneider, Ryan F; Kim, Haein; Lasek-Nesselquist, Erica; McDonough, Kathleen A; Agris, Paul F.

Afiliação

Väre VYP; Department of Biological Sciences, University at Albany-SUNY, Albany, New York, USA.
Schneider RF; Department of Biomedical Sciences, School of Public Health, University at Albany-SUNY, Albany, New York, USA.
Kim H; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Lasek-Nesselquist E; Wadsworth Center, New York State Department of Health, Albany, New York, USA.
McDonough KA; Department of Biomedical Sciences, School of Public Health, University at Albany-SUNY, Albany, New York, USA kathleen.mcdonough@health.ny.gov Paul.Agris@duke.edu.
Agris PF; Wadsworth Center, New York State Department of Health, Albany, New York, USA.

Antimicrob Agents Chemother ; 65(1)2020 12 16.

Article em En | MEDLINE | ID: mdl-33077662

Assuntos

Antibacterianos; Staphylococcus aureus Resistente à Meticilina; Antibacterianos/farmacologia; Expressão Gênica; Bactérias Gram-Positivas/genética; Staphylococcus aureus Resistente à Meticilina/genética; RNA de Transferência/genética

Palavras-chave

Gram-positive pathogens; antibiotic resistance; mRNA target for antibiotics; novel small-molecule antibiotics; synergy with common antibiotics; tRNA gene regulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Staphylococcus aureus Resistente à Meticilina / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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