Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor.

Siraj, Md Afjalus; Howlader, Md Sariful Islam; Rahaman, Md Sohanur; Shilpi, Jamil A; Seidel, Veronique

Siraj, Md Afjalus; Howlader, Md Sariful Islam; Rahaman, Md Sohanur; Shilpi, Jamil A; Seidel, Veronique.

Afiliação

Siraj MA; Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii, USA.
Howlader MSI; Department of Chemistry, Tennessee Technological University, Cookeville, Tennessee, USA.
Rahaman MS; Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh.
Shilpi JA; Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh.
Seidel V; Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

Phytother Res ; 35(2): 1069-1079, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33124164

Assuntos

Analgésicos/uso terapêutico; Canabinoides/uso terapêutico; Hipnóticos e Sedativos/uso terapêutico; Fenóis/uso terapêutico; Extratos Vegetais/química; Vernonia/química; Analgésicos/farmacologia; Animais; Canabinoides/farmacologia; Hipnóticos e Sedativos/farmacologia; Masculino; Camundongos; Fenóis/farmacologia

Palavras-chave

Vernonia patula; antinociceptive activity; cannabinoid receptor 1 (CB1); molecular docking

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenóis / Canabinoides / Extratos Vegetais / Vernonia / Analgésicos / Hipnóticos e Sedativos Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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