Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions.

Carlson, Christopher R; Asfaha, Jonathan B; Ghent, Chloe M; Howard, Conor J; Hartooni, Nairi; Safari, Maliheh; Frankel, Alan D; Morgan, David O

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions.

Carlson, Christopher R; Asfaha, Jonathan B; Ghent, Chloe M; Howard, Conor J; Hartooni, Nairi; Safari, Maliheh; Frankel, Alan D; Morgan, David O.

Afiliação

Carlson CR; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Asfaha JB; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Ghent CM; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA.
Howard CJ; Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Hartooni N; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Safari M; Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.
Frankel AD; Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Morgan DO; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: david.morgan@ucsf.edu.

Mol Cell ; 80(6): 1092-1103.e4, 2020 12 17.

Article em En | MEDLINE | ID: mdl-33248025

Assuntos

COVID-19; Proteínas do Nucleocapsídeo de Coronavírus/química; Multimerização Proteica; RNA Viral/química; SARS-CoV-2/química; Proteínas do Nucleocapsídeo de Coronavírus/genética; Proteínas do Nucleocapsídeo de Coronavírus/metabolismo; Humanos; Fosfoproteínas/química; Fosfoproteínas/genética; Fosfoproteínas/metabolismo; Fosforilação; Domínios Proteicos; RNA Viral/genética; RNA Viral/metabolismo; SARS-CoV-2/genética; SARS-CoV-2/metabolismo

Palavras-chave

COVID-19; Coronavirus; N protein; SARS-CoV-2; biomolecular condensate; nucleocapsid; phase separation; phosphorylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Viral / Multimerização Proteica / Proteínas do Nucleocapsídeo de Coronavírus / SARS-CoV-2 / COVID-19 Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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