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Bivalent antibody pliers inhibit ß-tryptase by an allosteric mechanism dependent on the IgG hinge.
Maun, Henry R; Vij, Rajesh; Walters, Benjamin T; Morando, Ashley; Jackman, Janet K; Wu, Ping; Estevez, Alberto; Chen, Xiaocheng; Franke, Yvonne; Lipari, Michael T; Dennis, Mark S; Kirchhofer, Daniel; Ciferri, Claudio; Loyet, Kelly M; Yi, Tangsheng; Eigenbrot, Charles; Lazarus, Robert A; Koerber, James T.
Afiliação
  • Maun HR; Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Vij R; Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Walters BT; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Morando A; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Jackman JK; Department of Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Wu P; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Estevez A; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Chen X; Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Franke Y; Department of Biomolecular Resources, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Lipari MT; Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Dennis MS; Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Kirchhofer D; Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Ciferri C; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Loyet KM; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Yi T; Department of Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Eigenbrot C; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Lazarus RA; Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. laz@gene.com.
  • Koerber JT; Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. koerberj@gene.com.
Nat Commun ; 11(1): 6435, 2020 12 22.
Article em En | MEDLINE | ID: mdl-33353951
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Triptases / Anticorpos Monoclonais Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Triptases / Anticorpos Monoclonais Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos