Aberrant RhoA activation in macrophages increases senescence-associated secretory phenotypes and ectopic calcification in muscular dystrophic mice.

Mu, Xiaodong; Lin, Chi-Yi; Hambright, William S; Tang, Ying; Ravuri, Sudheer; Lu, Aiping; Matre, Polina; Chen, Wanqun; Gao, Xueqin; Cui, Yan; Zhong, Ling; Wang, Bing; Huard, Johnny

Mu, Xiaodong; Lin, Chi-Yi; Hambright, William S; Tang, Ying; Ravuri, Sudheer; Lu, Aiping; Matre, Polina; Chen, Wanqun; Gao, Xueqin; Cui, Yan; Zhong, Ling; Wang, Bing; Huard, Johnny.

Afiliação

Mu X; Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Lin CY; Steadman Philippon Research Institute, Center for Regenerative Sports Medicine, Vail, CO 81657, USA.
Hambright WS; Department of Orthopedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Tang Y; Steadman Philippon Research Institute, Center for Regenerative Sports Medicine, Vail, CO 81657, USA.
Ravuri S; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Lu A; Steadman Philippon Research Institute, Center for Regenerative Sports Medicine, Vail, CO 81657, USA.
Matre P; Steadman Philippon Research Institute, Center for Regenerative Sports Medicine, Vail, CO 81657, USA.
Chen W; Department of Orthopedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Gao X; Department of Orthopedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Cui Y; Department of Biochemistry and Molecular Biology, Jinan University, Guangzhou, China.
Zhong L; Steadman Philippon Research Institute, Center for Regenerative Sports Medicine, Vail, CO 81657, USA.
Wang B; Department of Orthopedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Huard J; Department of Orthopedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Aging (Albany NY) ; 12(24): 24853-24871, 2020 12 23.

Article em En | MEDLINE | ID: mdl-33361519

Assuntos

Calcinose/metabolismo; Macrófagos/metabolismo; Músculo Esquelético/metabolismo; Distrofia Muscular Animal/metabolismo; Miocárdio/metabolismo; Quinases Associadas a rho/metabolismo; Proteína rhoA de Ligação ao GTP/metabolismo; Animais; Antígenos CD/metabolismo; Antígenos de Diferenciação Mielomonocítica/metabolismo; Calcinose/imunologia; Calcinose/patologia; Senescência Celular/genética; Senescência Celular/imunologia; Modelos Animais de Doenças; Distrofina/genética; Macrófagos/imunologia; Camundongos; Camundongos Knockout; Músculo Esquelético/imunologia; Músculo Esquelético/patologia; Distrofia Muscular Animal/genética; Distrofia Muscular Animal/imunologia; Distrofia Muscular Animal/patologia; Distrofia Muscular de Duchenne/genética; Distrofia Muscular de Duchenne/imunologia; Distrofia Muscular de Duchenne/metabolismo; Distrofia Muscular de Duchenne/patologia; Miocárdio/imunologia; Miocárdio/patologia; Utrofina/genética; Quinases Associadas a rho/imunologia; Proteína rhoA de Ligação ao GTP/imunologia

Palavras-chave

cellular senescence; chronic inflammation; heterotopic ossification; muscle dystrophy; muscle stem cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calcinose / Músculo Esquelético / Proteína rhoA de Ligação ao GTP / Quinases Associadas a rho / Macrófagos / Distrofia Muscular Animal / Miocárdio Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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