Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression.

Sugimoto, Kotaro; Ichikawa-Tomikawa, Naoki; Nishiura, Keisuke; Kunii, Yasuto; Sano, Yasuteru; Shimizu, Fumitaka; Kakita, Akiyoshi; Kanda, Takashi; Imura, Tetsuya; Chiba, Hideki

Sugimoto, Kotaro; Ichikawa-Tomikawa, Naoki; Nishiura, Keisuke; Kunii, Yasuto; Sano, Yasuteru; Shimizu, Fumitaka; Kakita, Akiyoshi; Kanda, Takashi; Imura, Tetsuya; Chiba, Hideki.

Afiliação

Sugimoto K; Department of Basic Pathology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Ichikawa-Tomikawa N; Department of Basic Pathology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Nishiura K; Department of Basic Pathology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Kunii Y; Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Sano Y; Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Shimizu F; Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Kakita A; Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Kanda T; Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Imura T; Department of Basic Pathology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Chiba H; Department of Basic Pathology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.

Int J Mol Sci ; 22(1)2020 Dec 29.

Article em En | MEDLINE | ID: mdl-33383868

Assuntos

Claudina-5/genética; Células Endoteliais/metabolismo; Regulação da Expressão Gênica; Acoplamento Neurovascular; Receptor 5-HT1A de Serotonina/metabolismo; Serotonina/metabolismo; Transdução de Sinais; Biomarcadores; Encéfalo/metabolismo; Comunicação Celular; Claudina-5/metabolismo; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Imunofluorescência; Humanos; Pericitos/patologia

Palavras-chave

5-HT1 receptor; PKA; blood-brain barrier; claudin; co-culture; endothelial cell; pericyte; psychiatric disorder; schizophrenia; tight junction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Serotonina / Regulação da Expressão Gênica / Células Endoteliais / Receptor 5-HT1A de Serotonina / Claudina-5 / Acoplamento Neurovascular Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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