XBP1s repression regulates Kupffer cell polarization leading to immune suppressive effects protecting liver allograft in rats.

Zhang, Weikang; Cao, Ding; Wang, Menghao; Wu, Yakun; Gong, Jianping; Li, Jingzheng; Liu, Yiming

Zhang, Weikang; Cao, Ding; Wang, Menghao; Wu, Yakun; Gong, Jianping; Li, Jingzheng; Liu, Yiming.

Afiliação

Zhang W; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China.
Cao D; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China. Electronic address: caoding88@163.com.
Wang M; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Wu Y; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Gong J; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Li J; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Liu Y; Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China. Electronic address: doctorliu@hospital.cqmu.edu.cn.

Int Immunopharmacol ; 91: 107294, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33395585

Assuntos

Rejeição de Enxerto/prevenção & controle; Sobrevivência de Enxerto; Células de Kupffer/metabolismo; Transplante de Fígado; Fígado/metabolismo; Proteína 1 de Ligação a X-Box/metabolismo; Aloenxertos; Animais; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD4-Positivos/metabolismo; Células Cultivadas; Técnicas de Cocultura; Citocinas/metabolismo; Rejeição de Enxerto/genética; Rejeição de Enxerto/imunologia; Rejeição de Enxerto/metabolismo; Janus Quinases/metabolismo; Células de Kupffer/imunologia; Fígado/imunologia; Fígado/cirurgia; Transplante de Fígado/efeitos adversos; Masculino; Fenótipo; Ratos Endogâmicos BN; Ratos Endogâmicos Lew; Fatores de Transcrição STAT/metabolismo; Transdução de Sinais; Proteína 1 de Ligação a X-Box/genética

Palavras-chave

JAK1-STAT1; Kupffer cells; Liver transplantation; M1/M2; T cells; XBP1s

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Proteína 1 de Ligação a X-Box / Rejeição de Enxerto / Sobrevivência de Enxerto / Células de Kupffer / Fígado Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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