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Hyaluronan-Based Three-Dimensional Microenvironment Potently Induces Cardiovascular Progenitor Cell Populations.
Gluck, Jessica M; Chyu, Jennifer; Delman, Connor; Heydarkhan-Hagvall, Sepideh; MacLellan, W Robb; Shemin, Richard J.
Afiliação
  • Gluck JM; Cardiovascular Tissue Engineering Laboratory, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, 62-151 CHS, Los Angeles, CA 90095-1741, USA.
  • Chyu J; Cardiovascular Research Laboratory, Departments of Medicine and Cardiology, David Geffen School of Medicine, University of California, Los Angeles, 675 Charles E. Young Drive South, MRL 3645, Los Angeles, CA 90095, USA.
  • Delman C; Cardiovascular Research Laboratory, Departments of Medicine and Cardiology, David Geffen School of Medicine, University of California, Los Angeles, 675 Charles E. Young Drive South, MRL 3645, Los Angeles, CA 90095, USA.
  • Heydarkhan-Hagvall S; Department of Medicine and Cardiology, University of Washington, 850 Republican Street, Brotman Room 432, Seattle, WA 98109, USA.
  • MacLellan WR; Cardiovascular Tissue Engineering Laboratory, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, 62-151 CHS, Los Angeles, CA 90095-1741, USA.
  • Shemin RJ; Cardiovascular Tissue Engineering Laboratory, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, 62-151 CHS, Los Angeles, CA 90095-1741, USA.
ISRN Tissue Eng ; 20132013.
Article em En | MEDLINE | ID: mdl-33426049
ABSTRACT
The relationship between stem cell niches in vivo and their surrounding microenvironment is still relatively unknown. Recent advances have indicated that extrinsic factors within the cardiovascular progenitor cell niche influence maintenance of a multipotent state as well as drive cell-fate decisions. We have previously shown the direct effects of extracellular matrix (ECM) proteins and have now investigated the effects of dimension on the induction of a cardiovascular progenitor cell (CPC) population. We have shown here that the three-dimensionality of a hyaluronan-based hydrogel greatly induces a CPC population, as marked by Flk-1. We have compared the effects of a 3D microenvironment to those of conventional 2D cell culture practices and have found that the 3D microenvironment potently induces a progenitor cell state.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos