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A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.
Noguchi, Tetsuji; Umezaki, Yuma; Takano, Rieko; Fujimoto, Teppei; Domon, Yuki; Kubota, Kazufumi; Ueda, Kenjiro; Kawase, Yumi; Yabe, Koichi; Yokoyama, Miki; Shimada, Kousei.
Afiliação
  • Noguchi T; Medicinal Chemistry Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Umezaki Y; Medicinal Chemistry Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Takano R; Medicinal Chemistry Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Fujimoto T; Medicinal Chemistry Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Domon Y; Specialty Medicine Research Laboratories I, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Kubota K; Specialty Medicine Research Laboratories I, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Ueda K; Specialty Medicine Research Laboratories I, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Kawase Y; Biomarker & Translational Research Department, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Yabe K; Pharmacovigilance Department, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Yokoyama M; Drug Metabolism & Pharmacokinetics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Shimada K; Medicinal Chemistry Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. Electronic address: shimada.kousei.ah@daiichisankyo.co.jp.
Bioorg Med Chem Lett ; 36: 127790, 2021 03 15.
Article em En | MEDLINE | ID: mdl-33454387
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Compostos Bicíclicos Heterocíclicos com Pontes / Aminas / Analgésicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Compostos Bicíclicos Heterocíclicos com Pontes / Aminas / Analgésicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão