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Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos, Pablo; Apóstolo, Nuno; Creemers, Eline; Callaerts-Vegh, Zsuzsanna; Swerts, Jef; Davies, Caitlin; McInnes, Joseph; Wierda, Keimpe; De Strooper, Bart; Spires-Jones, Tara; de Wit, Joris; Uytterhoeven, Valerie; Verstreken, Patrik.
Afiliação
  • Largo-Barrientos P; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium.
  • Apóstolo N; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium.
  • Creemers E; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium.
  • Callaerts-Vegh Z; KU Leuven, mINT Animal Behavior Facility, Faculty of Psychology, Leuven, Belgium.
  • Swerts J; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium.
  • Davies C; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • McInnes J; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium.
  • Wierda K; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium.
  • De Strooper B; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium; UK Dementia Research Institute, University College London, London, UK.
  • Spires-Jones T; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • de Wit J; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium.
  • Uytterhoeven V; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium. Electronic address: valerie.uytterhoeven@kuleuven.vib.be.
  • Verstreken P; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium. Electronic address: patrik.verstreken@kuleuven.vib.be.
Neuron ; 109(5): 767-777.e5, 2021 03 03.
Article em En | MEDLINE | ID: mdl-33472038
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Terminações Pré-Sinápticas / Microglia / Sinaptogirinas / Transtornos da Memória Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Terminações Pré-Sinápticas / Microglia / Sinaptogirinas / Transtornos da Memória Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Bélgica