The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial.
Arch Dermatol Res
; 313(10): 863-871, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-33550448
ABSTRACT
Platelet-rich plasma (PRP) showed positive results in the improvement of skin aging. Lyophilized PRP can be interesting in clinical practice due to the facility to obtain many samples in a single blood collection and can be used in multiple injections. To evaluate the effect of lyophilized PRP in the treatment of skin aging, through a Phase II pilot study. Nineteen women (54 years ± 7 years) with Glogau photoaging II and III types were select for this non-randomized, split-face controlled study. They received monthly intradermal injections of lyophilized PRP and saline solution (as control) into the facial skin, during a period of 2 months. The evaluation was performed by imaging method, histological techniques, and multiphoton microscopy. Although lyophilized PRP presented 10 times the platelet baseline value (P < .0001) and growth factors in adequate levels, only saline solution showed an increase of dermis thickness (p = .0009). Collagen pre and post-application remained the same for both types of treatments. The use of lyophilized PRP by mesotherapy showed no improvement on skin aging. TRIAL REGISTRATION APPROVAL RBR-3n9wxw, UTN U1111-1226-6093-retrospectively registered.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento da Pele
/
Plasma Rico em Plaquetas
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Mesoterapia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Brasil