Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington's Disease.

Zhao, Xiaonan; Kumari, Daman; Miller, Carson J; Kim, Geum-Yi; Hayward, Bruce; Vitalo, Antonia G; Pinto, Ricardo Mouro; Usdin, Karen

Zhao, Xiaonan; Kumari, Daman; Miller, Carson J; Kim, Geum-Yi; Hayward, Bruce; Vitalo, Antonia G; Pinto, Ricardo Mouro; Usdin, Karen.

Afiliação

Zhao X; Laboratory of Cell and Molecular Biology, National Institutes of Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Kumari D; Laboratory of Cell and Molecular Biology, National Institutes of Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Miller CJ; Laboratory of Cell and Molecular Biology, National Institutes of Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Kim GY; Laboratory of Cell and Molecular Biology, National Institutes of Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Hayward B; Laboratory of Cell and Molecular Biology, National Institutes of Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Vitalo AG; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Pinto RM; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Usdin K; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

J Huntingtons Dis ; 10(1): 149-163, 2021.

Article em En | MEDLINE | ID: mdl-33579860

Assuntos

Reparo de Erro de Pareamento de DNA/genética; Síndrome do Cromossomo X Frágil/genética; Ataxia de Friedreich/genética; Genes Modificadores/genética; Instabilidade Genômica/genética; Doença de Huntington/genética; Expansão das Repetições de Trinucleotídeos/genética; Animais; Humanos; Camundongos

Palavras-chave

FMR1-associated disorders; Fragile X-related disorders; Friedreich ataxia; Huntington's disease; base excision repair; double-strand break repair; mismatch repair; non-homologous end-joining; trinucleotide repeat instability

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ataxia de Friedreich / Doença de Huntington / Expansão das Repetições de Trinucleotídeos / Instabilidade Genômica / Reparo de Erro de Pareamento de DNA / Genes Modificadores / Síndrome do Cromossomo X Frágil Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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