Atypical teratoid/rhabdoid tumor in adult: case series and an integrated survival analysis.
Br J Neurosurg
; : 1-16, 2021 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-33595416
ABSTRACT
BACKGROUND:
Atypical teratoid/rhabdoid tumor (AT/RT) is well documented in children but less so in adults because of its rarity.METHOD:
We report a series of five cases, a literature review and quantitative analysis of the survival outcome of adult AT/RT patients.RESULTS:
Seventy-four patients including our five cases (male female = 16 58) were evaluated, whose median age was 32.5 years (18-80 years). The commonest location was the sellar region. Median overall survival (OS) was 12.5 months (0.5-204.00 months). Chemotherapy was associated with OS (HR 0.349, 95%CI 0.176-0.694, p = 0.003), while other factors did not influence OS. From Kaplan-Meier analysis, surgery combining postoperative chemotherapy and radiotherapy was associated with better prognosis (Log Rank χ2 = 14.662, p = 0.001).CONCLUSIONS:
Adult AT/RT is commoner in females and tends to recur rapidly after surgical resection. Chemotherapy may provide a survival benefit. Surgery combined with postoperative chemotherapy and radiotherapy was associated with better prognosis for adult AT/RT patients, though the overall prognosis was still poor.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China