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Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses.
Lo, Jennifer A; Kawakubo, Masayoshi; Juneja, Vikram R; Su, Mack Y; Erlich, Tal H; LaFleur, Martin W; Kemeny, Lajos V; Rashid, Mamunur; Malehmir, Mohsen; Rabi, S Alireza; Raghavan, Rumya; Allouche, Jennifer; Kasumova, Gyulnara; Frederick, Dennie T; Pauken, Kristen E; Weng, Qing Yu; Pereira da Silva, Marcelo; Xu, Yu; van der Sande, Anita A J; Silkworth, Whitney; Roider, Elisabeth; Browne, Edward P; Lieb, David J; Wang, Belinda; Garraway, Levi A; Wu, Catherine J; Flaherty, Keith T; Brinckerhoff, Constance E; Mullins, David W; Adams, David J; Hacohen, Nir; Hoang, Mai P; Boland, Genevieve M; Freeman, Gordon J; Sharpe, Arlene H; Manstein, Dieter; Fisher, David E.
Afiliação
  • Lo JA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Kawakubo M; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  • Juneja VR; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Su MY; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Erlich TH; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
  • LaFleur MW; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Kemeny LV; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  • Rashid M; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Malehmir M; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  • Rabi SA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Raghavan R; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Allouche J; Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  • Kasumova G; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Frederick DT; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  • Pauken KE; Experimental Cancer Genetics, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
  • Weng QY; Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Pereira da Silva M; Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Xu Y; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • van der Sande AAJ; Harvard-MIT Health Sciences and Technology Program, Cambridge, MA 02139, USA.
  • Silkworth W; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Roider E; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  • Browne EP; Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Lieb DJ; Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Wang B; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Garraway LA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Wu CJ; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Flaherty KT; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  • Brinckerhoff CE; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Mullins DW; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Adams DJ; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Hacohen N; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  • Hoang MP; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Boland GM; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  • Freeman GJ; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Sharpe AH; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  • Manstein D; Department of Dermatology and Allergology, University of Szeged, Szeged 6727, Hungary.
  • Fisher DE; Department of Dermatology, Venerology, and Allergology, Kantonsspital St. Gallen, St. Gallen 9000, Switzerland.
Sci Transl Med ; 13(581)2021 02 17.
Article em En | MEDLINE | ID: mdl-33597266
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Checkpoint Imunológico / Melanoma Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Checkpoint Imunológico / Melanoma Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos