Pygo1 regulates pathological cardiac hypertrophy via a ß-catenin-dependent mechanism.

Lin, Li; Xu, Wei; Li, Yongqing; Zhu, Ping; Yuan, Wuzhou; Liu, Ming; Shi, Yan; Chen, Yu; Liang, Jifeng; Chen, Jimei; Yang, Boyu; Cai, Wanwan; Wen, Yao; Zhu, Xiaolan; Peng, Xiyang; Zhou, Zuoqiong; Mo, Xiaoyang; Wan, Yongqi; Yuan, Haiyun; Li, Fang; Ye, Xiangli; Jiang, Zhigang; Wang, Yuequn; Zhuang, Jian; Fan, Xiongwei; Wu, Xiushan

Pygo1 regulates pathological cardiac hypertrophy via a ß-catenin-dependent mechanism.

Lin, Li; Xu, Wei; Li, Yongqing; Zhu, Ping; Yuan, Wuzhou; Liu, Ming; Shi, Yan; Chen, Yu; Liang, Jifeng; Chen, Jimei; Yang, Boyu; Cai, Wanwan; Wen, Yao; Zhu, Xiaolan; Peng, Xiyang; Zhou, Zuoqiong; Mo, Xiaoyang; Wan, Yongqi; Yuan, Haiyun; Li, Fang; Ye, Xiangli; Jiang, Zhigang; Wang, Yuequn; Zhuang, Jian; Fan, Xiongwei; Wu, Xiushan.

Afiliação

Lin L; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Xu W; Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
Li Y; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Zhu P; Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yuan W; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Liu M; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Shi Y; Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Chen Y; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Liang J; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Chen J; Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yang B; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Cai W; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Wen Y; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Zhu X; Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Peng X; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Zhou Z; Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Mo X; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Wan Y; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Yuan H; Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Li F; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Ye X; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Jiang Z; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Wang Y; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Zhuang J; Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Fan X; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S
Wu X; The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life S

Am J Physiol Heart Circ Physiol ; 320(4): H1634-H1645, 2021 04 01.

Article em En | MEDLINE | ID: mdl-33635162

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Insuficiência Cardíaca/metabolismo; Hipertrofia Ventricular Esquerda/metabolismo; Miocárdio/metabolismo; Função Ventricular Esquerda; Remodelação Ventricular; Via de Sinalização Wnt; beta Catenina/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Animais; Proteína Axina/genética; Proteína Axina/metabolismo; Modelos Animais de Doenças; Insuficiência Cardíaca/induzido quimicamente; Insuficiência Cardíaca/patologia; Insuficiência Cardíaca/prevenção & controle; Hipertrofia Ventricular Esquerda/induzido quimicamente; Hipertrofia Ventricular Esquerda/tratamento farmacológico; Hipertrofia Ventricular Esquerda/patologia; Isoproterenol; Masculino; Camundongos Transgênicos; Miocárdio/patologia; Proteínas Proto-Oncogênicas c-myc/genética; Proteínas Proto-Oncogênicas c-myc/metabolismo; Ratos; Receptor EphB3/genética; Receptor EphB3/metabolismo; Tiazolidinas/farmacologia; Fator de Transcrição 4/genética; Fator de Transcrição 4/metabolismo; Função Ventricular Esquerda/efeitos dos fármacos; Remodelação Ventricular/efeitos dos fármacos; Via de Sinalização Wnt/efeitos dos fármacos; beta Catenina/antagonistas & inibidores

Palavras-chave

Pygo1; Wnt/ß-catenin signaling; cardiac hypertrophy

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Função Ventricular Esquerda / Hipertrofia Ventricular Esquerda / Remodelação Ventricular / Proteínas Adaptadoras de Transdução de Sinal / Beta Catenina / Via de Sinalização Wnt / Insuficiência Cardíaca / Miocárdio Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google