In vitro and in vivo studies reveal &#945;-Mangostin, a xanthonoid from Garcinia mangostana, as a promising natural antiviral compound against chikungunya virus.

Patil, Poonam; Agrawal, Megha; Almelkar, Shahdab; Jeengar, Manish Kumar; More, Ashwini; Alagarasu, Kalichamy; Kumar, Naveen V; Mainkar, Prathama S; Parashar, Deepti; Cherian, Sarah

In vitro and in vivo studies reveal α-Mangostin, a xanthonoid from Garcinia mangostana, as a promising natural antiviral compound against chikungunya virus.

Patil, Poonam; Agrawal, Megha; Almelkar, Shahdab; Jeengar, Manish Kumar; More, Ashwini; Alagarasu, Kalichamy; Kumar, Naveen V; Mainkar, Prathama S; Parashar, Deepti; Cherian, Sarah.

Afiliação

Patil P; ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune, Maharashtra, 411001, India.
Agrawal M; ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune, Maharashtra, 411001, India.
Almelkar S; ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune, Maharashtra, 411001, India.
Jeengar MK; ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune, Maharashtra, 411001, India.
More A; ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune, Maharashtra, 411001, India.
Alagarasu K; ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune, Maharashtra, 411001, India.
Kumar NV; CSIR-Indian Institute of Chemical Technology [CSIR-IICT, Hyderabad, 500 007, India.
Mainkar PS; CSIR-Indian Institute of Chemical Technology [CSIR-IICT, Hyderabad, 500 007, India.
Parashar D; ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune, Maharashtra, 411001, India. parashar.d@gov.in.
Cherian S; ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune, Maharashtra, 411001, India. cherian.ss@gov.in.

Virol J ; 18(1): 47, 2021 02 28.

Article em En | MEDLINE | ID: mdl-33639977

Assuntos

Antivirais/farmacologia; Vírus Chikungunya; Garcinia mangostana; Xantonas/farmacologia; Animais; Febre de Chikungunya/tratamento farmacológico; Vírus Chikungunya/efeitos dos fármacos; Chlorocebus aethiops; Garcinia mangostana/química; Camundongos; Simulação de Acoplamento Molecular; Células Vero; Replicação Viral/efeitos dos fármacos

Palavras-chave

Antiviral therapy; Chikungunya; Treatment; Xanthonoids; Α-Mangostin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Vírus Chikungunya / Garcinia mangostana / Xantonas Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia

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