Protean Regulation of Leukocyte Function by Nuclear Lamins.
Trends Immunol
; 42(4): 323-335, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33653660
ABSTRACT
The leukocyte nucleus must be sufficiently elastic to squeeze through tissue barriers during migration, but not so collapsible as to risk damaging chromatin. The proper balance is struck in part by the composition of the nuclear lamina, a flexible meshwork composed mainly of intermediate filaments woven from type A and type B lamin proteins, that is located subjacent to the inner nuclear membrane. There is now increasing evidence that, in addition to influencing nuclear shape and stiffness and cell migration, lamins and lamin-interacting proteins may also interact functionally with chromatin to influence leukocyte gene expression, differentiation, and effector function, including T cell differentiation, B cell somatic hypermutation, and the formation of neutrophil extracellular traps (NETosis).
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Filamentos Intermediários
/
Lâmina Nuclear
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article