Recognition of artificial microstructures by sensory nerve fibers in culture.
Brain Res
; 446(1): 189-94, 1988 Apr 12.
Article
em En
| MEDLINE
| ID: mdl-3370482
ABSTRACT
Dissociated culture of adult mouse dorsal root ganglion cells on glass plates, on which grating-associated microstructures (a repetition of microgrooves [mGRV] and microsteps [mSTP] of 0.1-10 micron) are fabricated by the conventional lithographic techniques, represents a remarkable bi-directional growth of their nerve fibers in the axial direction of the grating. Microscopical observation shows that the nerve fibers prefer to grow in the mGRV (70%), while their growth cones exhibit an even distribution onto the mGRV and mSTP. The efficiency of the nerve fibers to grow along the grating-axis are highly sensitive to a fine alteration of the width and depth of the mGRV. The preferential growth of the nerve fibers is thus due to a mechanical recognition of the microstructures by the growth cones and neurites.
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Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Fibras Nervosas
/
Neurônios Aferentes
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Japão