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Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
Yang, Wanchun; Pang, Dejiang; Chen, Mina; Du, Chongyangzi; Jia, Lanlan; Wang, Luoling; He, Yunling; Jiang, Wanxiang; Luo, Liping; Yu, Zongyan; Mao, Mengqian; Yuan, Qiuyun; Tang, Ping; Xia, Xiaoqiang; Cui, Yiyuan; Jing, Bo; Platero, Alexander; Liu, Yanhui; Wei, Yuquan; Worley, Paul F; Xiao, Bo.
Afiliação
  • Yang W; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Pang D; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Chen M; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Du C; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Jia L; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Wang L; Department of Biology, School of Life Sciences, Brain Research Center, Southern University of Science and Technology, Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Shenzhen 518055, People's Republic of China.
  • He Y; Department of Biology, School of Life Sciences, Brain Research Center, Southern University of Science and Technology, Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Shenzhen 518055, People's Republic of China.
  • Jiang W; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Luo L; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Yu Z; Department of Biology, School of Life Sciences, Brain Research Center, Southern University of Science and Technology, Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Shenzhen 518055, People's Republic of China.
  • Mao M; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Yuan Q; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Tang P; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Xia X; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Cui Y; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Jing B; Department of Biology, School of Life Sciences, Brain Research Center, Southern University of Science and Technology, Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Shenzhen 518055, People's Republic of China.
  • Platero A; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Liu Y; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Wei Y; Neuroscience & Metabolism Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Worley PF; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: pworley@jhmi.edu.
  • Xiao B; Department of Biology, School of Life Sciences, Brain Research Center, Southern University of Science and Technology, Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Shenzhen 518055, People's Republic of China. Electronic address: xiaob@sustech.edu.cn.
Dev Cell ; 56(6): 811-825.e6, 2021 03 22.
Article em En | MEDLINE | ID: mdl-33725483
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexo Piruvato Desidrogenase / Metabolismo Energético / Alvo Mecanístico do Complexo 1 de Rapamicina / Proteína Enriquecida em Homólogo de Ras do Encéfalo / Mitocôndrias / Neurônios Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexo Piruvato Desidrogenase / Metabolismo Energético / Alvo Mecanístico do Complexo 1 de Rapamicina / Proteína Enriquecida em Homólogo de Ras do Encéfalo / Mitocôndrias / Neurônios Idioma: En Ano de publicação: 2021 Tipo de documento: Article