Beyond pacemaking: HCN channels in sinoatrial node function.
Prog Biophys Mol Biol
; 166: 51-60, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-33753086
ABSTRACT
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key proteins involved in the initiation and regulation of the heartbeat. Pacemaker cells within the sinoatrial node generate the electrical impulse that underlies the contraction of all atrial and ventricular cardiomyocytes. To generate a stable heart rhythm, it is necessary that the spontaneous activity of pacemaker cells is synchronized. Entrainment processes in the sinoatrial node create synchrony and also mediate heart rate regulation. In the past years it has become clear that the role of HCN channels goes beyond just pacemaking and that the channels play pivotal roles in these entrainment processes that coordinate and balance sinoatrial node network activity. Here, we review the role of HCN channels in the central pacemaker process and highlight new aspects of the contribution of HCN channels to stabilizing the electrical activity of the sinoatrial node network, especially during heart rate regulation by the autonomic nervous system.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nó Sinoatrial
/
Canais Disparados por Nucleotídeos Cíclicos Ativados por Hiperpolarização
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha