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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative Immunoglobulin G Assays: The Value of Numeric Reporting.
Forest, Stefanie K; Orner, Erika P; Goldstein, D Yitzchak; Wirchnianski, Ariel S; Bortz, Robert H; Laudermilch, Ethan; Florez, Catalina; Malonis, Ryan J; Georgiev, George I; Vergnolle, Olivia; Lo, Yungtai; Campbell, Sean T; Barnhill, Jason; Cadoff, Evan M; Lai, Jonathan R; Chandran, Kartik; Weiss, Louis M; Fox, Amy S; Prystowsky, Michael B; Wolgast, Lucia R.
Afiliação
  • Forest SK; From the Department of Pathology (Forest, Orner, Goldstein, Campbell, Cadoff, Weiss, Fox, Prystowsky, Wolgast), Bronx, New York.
  • Orner EP; From the Department of Pathology (Forest, Orner, Goldstein, Campbell, Cadoff, Weiss, Fox, Prystowsky, Wolgast), Bronx, New York.
  • Goldstein DY; From the Department of Pathology (Forest, Orner, Goldstein, Campbell, Cadoff, Weiss, Fox, Prystowsky, Wolgast), Bronx, New York.
  • Wirchnianski AS; Department of Microbiology and Immunology (Wirchnianski, Bortz, Laudermilch, Florez, Chandran), Bronx, New York.
  • Bortz RH; Department of Microbiology and Immunology (Wirchnianski, Bortz, Laudermilch, Florez, Chandran), Bronx, New York.
  • Laudermilch E; Department of Microbiology and Immunology (Wirchnianski, Bortz, Laudermilch, Florez, Chandran), Bronx, New York.
  • Florez C; Department of Microbiology and Immunology (Wirchnianski, Bortz, Laudermilch, Florez, Chandran), Bronx, New York.
  • Malonis RJ; Albert Einstein College of Medicine, Bronx, New York; the Department of Chemistry and Life Sciences, United States Military Academy, West Point, New York (Florez, Barnhill).
  • Georgiev GI; Department of Biochemistry (Malonis, Georgiev, Vergnolle, Lai), Bronx, New York.
  • Vergnolle O; Department of Biochemistry (Malonis, Georgiev, Vergnolle, Lai), Bronx, New York.
  • Lo Y; Department of Biochemistry (Malonis, Georgiev, Vergnolle, Lai), Bronx, New York.
  • Campbell ST; Department of Epidemiology and Population Medicine (Lo), Bronx, New York.
  • Barnhill J; From the Department of Pathology (Forest, Orner, Goldstein, Campbell, Cadoff, Weiss, Fox, Prystowsky, Wolgast), Bronx, New York.
  • Cadoff EM; Albert Einstein College of Medicine, Bronx, New York; the Department of Chemistry and Life Sciences, United States Military Academy, West Point, New York (Florez, Barnhill).
  • Lai JR; The Department of Radiology, Uniformed Services University of Health Science, Bethesda, Maryland (Barnhill).
  • Chandran K; From the Department of Pathology (Forest, Orner, Goldstein, Campbell, Cadoff, Weiss, Fox, Prystowsky, Wolgast), Bronx, New York.
  • Weiss LM; Department of Biochemistry (Malonis, Georgiev, Vergnolle, Lai), Bronx, New York.
  • Fox AS; Department of Microbiology and Immunology (Wirchnianski, Bortz, Laudermilch, Florez, Chandran), Bronx, New York.
  • Prystowsky MB; From the Department of Pathology (Forest, Orner, Goldstein, Campbell, Cadoff, Weiss, Fox, Prystowsky, Wolgast), Bronx, New York.
  • Wolgast LR; From the Department of Pathology (Forest, Orner, Goldstein, Campbell, Cadoff, Weiss, Fox, Prystowsky, Wolgast), Bronx, New York.
Arch Pathol Lab Med ; 145(8): 929-936, 2021 08 01.
Article em En | MEDLINE | ID: mdl-33821952
CONTEXT.­: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) testing is used for serosurveillance and will be important to evaluate vaccination status. Given the urgency to release coronavirus disease 2019 (COVID-19) serology tests, most manufacturers have developed qualitative tests. OBJECTIVE.­: To evaluate clinical performance of 6 different SARS-CoV-2 IgG assays and their quantitative results to better elucidate the clinical role of serology testing in COVID-19. DESIGN.­: Six SARS-CoV-2 IgG assays were tested using remnant specimens from 190 patients. Sensitivity and specificity were evaluated for each assay with the current manufacturer's cutoff and a lower cutoff. A numeric result analysis and discrepancy analysis were performed. RESULTS.­: Specificity was higher than 93% for all assays, and sensitivity was higher than 80% for all assays (≥7 days post-polymerase chain reaction testing). Inpatients with more severe disease had higher numeric values compared with health care workers with mild or moderate disease. Several discrepant serology results were those just below the manufacturers' cutoff. CONCLUSIONS.­: Severe acute respiratory syndrome coronavirus 2 IgG antibody testing can aid in the diagnosis of COVID-19, especially with negative polymerase chain reaction. Quantitative COVID-19 IgG results are important to better understand the immunologic response and disease course of this novel virus and to assess immunity as part of future vaccination programs.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Teste Sorológico para COVID-19 / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais País/Região como assunto: America do norte Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Teste Sorológico para COVID-19 / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais País/Região como assunto: America do norte Idioma: En Ano de publicação: 2021 Tipo de documento: Article