Ivacaftor partially corrects airway inflammation in a humanized G551D rat.

Green, Morgan; Lindgren, Natalie; Henderson, Alexander; Keith, Johnathan D; Oden, Ashley M; Birket, Susan E

Green, Morgan; Lindgren, Natalie; Henderson, Alexander; Keith, Johnathan D; Oden, Ashley M; Birket, Susan E.

Afiliação

Green M; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Lindgren N; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Henderson A; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Keith JD; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Oden AM; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Birket SE; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Am J Physiol Lung Cell Mol Physiol ; 320(6): L1093-L1100, 2021 06 01.

Article em En | MEDLINE | ID: mdl-33825507

Assuntos

Aminofenóis/farmacologia; Fibrose Cística/tratamento farmacológico; Inflamação/tratamento farmacológico; Transporte de Íons/efeitos dos fármacos; Quinolonas/farmacologia; Animais; Regulador de Condutância Transmembrana em Fibrose Cística/efeitos dos fármacos; Pulmão/efeitos dos fármacos; Terapia de Alvo Molecular/métodos; Depuração Mucociliar/efeitos dos fármacos; Ratos Transgênicos

Palavras-chave

G551D; cystic fibrosis; inflammation; ivacaftor; rat

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transporte de Íons / Quinolonas / Fibrose Cística / Aminofenóis / Inflamação Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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