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Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
Trudler, Dorit; Nazor, Kristopher L; Eisele, Yvonne S; Grabauskas, Titas; Dolatabadi, Nima; Parker, James; Sultan, Abdullah; Zhong, Zhenyu; Goodwin, Marshall S; Levites, Yona; Golde, Todd E; Kelly, Jeffery W; Sierks, Michael R; Schork, Nicholas J; Karin, Michael; Ambasudhan, Rajesh; Lipton, Stuart A.
Afiliação
  • Trudler D; Neurodegeneration New Medicines Center, The Scripps Research Institute, La Jolla, CA 92037.
  • Nazor KL; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Eisele YS; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121.
  • Grabauskas T; MYi Diagnostics & Discovery, San Diego, CA 92121.
  • Dolatabadi N; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Parker J; Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15219.
  • Sultan A; Neurodegeneration New Medicines Center, The Scripps Research Institute, La Jolla, CA 92037.
  • Zhong Z; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Goodwin MS; Neurodegeneration New Medicines Center, The Scripps Research Institute, La Jolla, CA 92037.
  • Levites Y; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Golde TE; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121.
  • Kelly JW; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121.
  • Sierks MR; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121.
  • Schork NJ; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA 92093.
  • Karin M; Department of Pathology, University of California San Diego School of Medicine, La Jolla, CA 92093.
  • Ambasudhan R; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Lipton SA; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610.
Proc Natl Acad Sci U S A ; 118(15)2021 04 13.
Article em En | MEDLINE | ID: mdl-33833060

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Microglia / Alfa-Sinucleína / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Microglia / Alfa-Sinucleína / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Idioma: En Ano de publicação: 2021 Tipo de documento: Article