Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide­induced acute liver injury.

Liu, Miaomiao; Zheng, Bin; Liu, Panpan; Zhang, Jianping; Chu, Xi; Dong, Chunhui; Shi, Jing; Liang, Yingran; Chu, Li; Liu, Yanshuang; Han, Xue

Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxideinduced acute liver injury.

Liu, Miaomiao; Zheng, Bin; Liu, Panpan; Zhang, Jianping; Chu, Xi; Dong, Chunhui; Shi, Jing; Liang, Yingran; Chu, Li; Liu, Yanshuang; Han, Xue.

Afiliação

Liu M; Department of Pharmacology, School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Zheng B; Department of Pharmacology, School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Liu P; Department of Pharmacology, School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Zhang J; Department of Pharmacology, School of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Chu X; Department of Pharmacy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
Dong C; Department of Pharmacy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
Shi J; Department of Pharmacy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
Liang Y; Department of Pharmacology, School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Chu L; Department of Pharmacology, School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Liu Y; Hebei Key Laboratory of Integrative Medicine on LiverKidney Patterns, Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Han X; Department of Pharmacology, School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.

Mol Med Rep ; 23(6)2021 06.

Article em En | MEDLINE | ID: mdl-33846815

Assuntos

Trióxido de Arsênio/efeitos adversos; Fígado/efeitos dos fármacos; Fígado/lesões; Substâncias Protetoras/farmacologia; Saponinas/farmacologia; Triterpenos/farmacologia; Animais; Anti-Inflamatórios/farmacologia; Antioxidantes/farmacologia; Apoptose/efeitos dos fármacos; Citocinas/metabolismo; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Fígado/metabolismo; Fígado/patologia; Masculino; Camundongos; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Substâncias Protetoras/química; Espécies Reativas de Oxigênio/metabolismo; Saponinas/química; Transdução de Sinais/efeitos dos fármacos; Triterpenos/química

Palavras-chave

magnesium isoglycyrrhizinate; arsenic trioxide; inflammatory; apoptosis; oxidative stress; Kelchlike ECHassociated protein1/nuclear factor erythroid2related factor2 signaling pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saponinas / Triterpenos / Substâncias Protetoras / Trióxido de Arsênio / Fígado Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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