Environmental factors in non-syndromic orofacial clefts: A review based on meta-analyses results.
Oral Dis
; 28(1): 3-8, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-33872445
ABSTRACT
Non-syndromic orofacial clefts (NSOFCs) are prevalent birth defects with a complex etiology where several interacting genetic and environmental factors have been observed. This narrative review describes maternal exposures that have been significantly associated with protective effects or risk factors. The statistically significant information reported here was found in meta-analysis studies, taking advantage of their precision in defining intervention effects and their management of heterogeneity between studies. In addition, I propose a hypothesis explaining the biological basis for the results of the meta-analyses. This review aims to improve the evidence available in parent counseling, to prevent the occurrence of orofacial clefts by suggesting lifestyle changes.
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MEDLINE
Assunto principal:
Fenda Labial
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Fissura Palatina
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Chile