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Integration of evidence across human and model organism studies: A meeting report.
Palmer, Rohan H C; Johnson, Emma C; Won, Hyejung; Polimanti, Renato; Kapoor, Manav; Chitre, Apurva; Bogue, Molly A; Benca-Bachman, Chelsie E; Parker, Clarissa C; Verma, Anurag; Reynolds, Timothy; Ernst, Jason; Bray, Michael; Kwon, Soo Bin; Lai, Dongbing; Quach, Bryan C; Gaddis, Nathan C; Saba, Laura; Chen, Hao; Hawrylycz, Michael; Zhang, Shan; Zhou, Yuan; Mahaffey, Spencer; Fischer, Christian; Sanchez-Roige, Sandra; Bandrowski, Anita; Lu, Qing; Shen, Li; Philip, Vivek; Gelernter, Joel; Bierut, Laura J; Hancock, Dana B; Edenberg, Howard J; Johnson, Eric O; Nestler, Eric J; Barr, Peter B; Prins, Pjotr; Smith, Desmond J; Akbarian, Schahram; Thorgeirsson, Thorgeir; Walton, Dave; Baker, Erich; Jacobson, Daniel; Palmer, Abraham A; Miles, Michael; Chesler, Elissa J; Emerson, Jake; Agrawal, Arpana; Martone, Maryann; Williams, Robert W.
Afiliação
  • Palmer RHC; Behavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, Georgia, USA.
  • Johnson EC; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Won H; Department of Genetics and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Polimanti R; Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA.
  • Kapoor M; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Chitre A; Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
  • Bogue MA; The Jackson Laboratory, Bar Harbor, Maine, USA.
  • Benca-Bachman CE; Behavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, Georgia, USA.
  • Parker CC; Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
  • Verma A; Biomedical and Translational Informatics Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Reynolds T; The Jackson Laboratory, Bar Harbor, Maine, USA.
  • Ernst J; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA.
  • Bray M; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Kwon SB; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA.
  • Lai D; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Quach BC; GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.
  • Gaddis NC; GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.
  • Saba L; Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
  • Chen H; Department of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Hawrylycz M; Allen Institute, Seattle, Washington, USA.
  • Zhang S; Department of Statistics and Probability, Michigan State University, East Lansing, Michigan, USA.
  • Zhou Y; Department of Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
  • Mahaffey S; Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, Colorado, USA.
  • Fischer C; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Sanchez-Roige S; Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
  • Bandrowski A; Department of Neuroscience, University of California, San Diego, La Jolla, California, USA.
  • Lu Q; Department of Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
  • Shen L; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Philip V; The Jackson Laboratory, Bar Harbor, Maine, USA.
  • Gelernter J; Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA.
  • Bierut LJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Hancock DB; GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.
  • Edenberg HJ; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Johnson EO; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Nestler EJ; GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.
  • Barr PB; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Prins P; Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Smith DJ; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Akbarian S; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
  • Thorgeirsson T; Friedman Brain Institute and Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Walton D; deCODE Genetics/Amgen Inc., Reykjavik, Iceland.
  • Baker E; The Jackson Laboratory, Bar Harbor, Maine, USA.
  • Jacobson D; Department of Computer Science, Baylor University, Waco, Texas, USA.
  • Palmer AA; Computational and Predictive Biology, Biosciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
  • Miles M; Department of Psychology, University of Tennessee Knoxville, Knoxville, Tennessee, USA.
  • Chesler EJ; Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
  • Emerson J; Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.
  • Agrawal A; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Martone M; The Jackson Laboratory, Bar Harbor, Maine, USA.
  • Williams RW; The Jackson Laboratory, Bar Harbor, Maine, USA.
Genes Brain Behav ; : e12738, 2021 Apr 23.
Article em En | MEDLINE | ID: mdl-33893716
The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration-particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos