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Palladium-Catalyzed ß-C(sp3)-H Arylation of Aliphatic Ketones Enabled by a Transient Directing Group.
Wang, Yangyang; Wu, Gaorong; Xu, Xiaobo; Pang, Binghan; Liao, Shaowen; Ji, Yafei.
Afiliação
  • Wang Y; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P.R. China.
  • Wu G; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P.R. China.
  • Xu X; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P.R. China.
  • Pang B; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P.R. China.
  • Liao S; Shanghai Jinli Pharmaceutical Co. Ltd., 108 Yuegong Road, Shanghai 201507, P.R. China.
  • Ji Y; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P.R. China.
J Org Chem ; 86(10): 7296-7303, 2021 05 21.
Article em En | MEDLINE | ID: mdl-33950672
ABSTRACT
The direct arylation of aliphatic ketones has been developed via Pd-catalyzed ß-C(sp3)-H bond functionalization with 2-(aminooxy)-N,N-dimethylacetamide as a novel transient directing group (TDG), which showed remarkable directing ability to generate arylated products in moderate to good yields. Furthermore, the reaction can tolerate abundant substrate of ketones and aryl iodides. This study expands the scope of applications for TDGs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Paládio / Cetonas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Paládio / Cetonas Idioma: En Ano de publicação: 2021 Tipo de documento: Article