Suppression of ACADM-Mediated Fatty Acid Oxidation Promotes Hepatocellular Carcinoma via Aberrant CAV1/SREBP1 Signaling.

Ma, Angel P Y; Yeung, Cherlie L S; Tey, Sze Keong; Mao, Xiaowen; Wong, Samuel W K; Ng, Tung Him; Ko, Frankie C F; Kwong, Ernest M L; Tang, Alexander H N; Ng, Irene Oi-Lin; Cai, Shao Hang; Yun, Jing Ping; Yam, Judy W P

Ma, Angel P Y; Yeung, Cherlie L S; Tey, Sze Keong; Mao, Xiaowen; Wong, Samuel W K; Ng, Tung Him; Ko, Frankie C F; Kwong, Ernest M L; Tang, Alexander H N; Ng, Irene Oi-Lin; Cai, Shao Hang; Yun, Jing Ping; Yam, Judy W P.

Afiliação

Ma APY; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Yeung CLS; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Tey SK; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Mao X; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Wong SWK; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ng TH; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ko FCF; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Kwong EML; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Tang AHN; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ng IO; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Cai SH; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.
Yun JP; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yam JWP; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China.

Cancer Res ; 81(13): 3679-3692, 2021 07 01.

Article em En | MEDLINE | ID: mdl-33975883

Assuntos

Acil-CoA Desidrogenase/antagonistas & inibidores; Biomarcadores Tumorais/metabolismo; Carcinoma Hepatocelular/patologia; Caveolina 1/metabolismo; Ácidos Graxos/química; Regulação Neoplásica da Expressão Gênica; Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo; Acil-CoA Desidrogenase/genética; Acil-CoA Desidrogenase/metabolismo; Animais; Apoptose; Biomarcadores Tumorais/genética; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Caveolina 1/genética; Proliferação de Células; Humanos; Metabolismo dos Lipídeos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Oxirredução; Prognóstico; Proteína de Ligação a Elemento Regulador de Esterol 1/genética; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Carcinoma Hepatocelular / Acil-CoA Desidrogenase / Caveolina 1 / Proteína de Ligação a Elemento Regulador de Esterol 1 / Ácidos Graxos Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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