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Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.
Vecchio, Laura M; Sullivan, Patricia; Dunn, Amy R; Bermejo, Marie Kristel; Fu, Rong; Masoud, Shababa T; Gregersen, Emil; Urs, Nikhil M; Nazari, Reza; Jensen, Poul Henning; Ramsey, Amy; Goldstein, David S; Miller, Gary W; Salahpour, Ali.
Afiliação
  • Vecchio LM; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Sullivan P; Autonomic Medicine Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological, Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Dunn AR; The Jackson Laboratory. Bar Harbor, Maine, USA.
  • Bermejo MK; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Fu R; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.
  • Masoud ST; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Gregersen E; Danish Research Institute of Translational Neuroscience - DANDRITE, Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus C., Denmark.
  • Urs NM; Department of Pharmacology and Therapeutics, University of Florida, Gainsville, FL, USA.
  • Nazari R; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Jensen PH; Danish Research Institute of Translational Neuroscience - DANDRITE, Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus C., Denmark.
  • Ramsey A; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Goldstein DS; Autonomic Medicine Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological, Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Miller GW; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Centre, New York, NY, USA.
  • Salahpour A; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
J Neurochem ; 158(4): 960-979, 2021 08.
Article em En | MEDLINE | ID: mdl-33991113
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina 3-Mono-Oxigenase / Catecolaminas / Estresse Oxidativo / Anfetamina / Estimulantes do Sistema Nervoso Central Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina 3-Mono-Oxigenase / Catecolaminas / Estresse Oxidativo / Anfetamina / Estimulantes do Sistema Nervoso Central Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá