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Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses.
Dilliott, Allison A; Sunderland, Kelly M; McLaughlin, Paula M; Roberts, Angela C; Evans, Emily C; Abrahao, Agessandro; Binns, Malcolm A; Black, Sandra E; Borrie, Michael; Casaubon, Leanne K; Dowlatshahi, Dar; Finger, Elizabeth; Fischer, Corinne E; Frank, Andrew; Freedman, Morris; Grimes, David; Hassan, Ayman; Jog, Mandar; Kumar, Sanjeev; Kwan, Donna; Lang, Anthony E; Mandzia, Jennifer; Marras, Connie; Masellis, Mario; McIntyre, Adam D; Pasternak, Stephen; Pollock, Bruce G; Rajji, Tarek K; Robinson, John F; Rogaeva, Ekaterina; Sahlas, Demetrios J; Saposnik, Gustavo; Sato, Christine; Seitz, Dallas; Shoesmith, Christen; Steeves, Thomas; Strother, Stephen C; Swartz, Richard H; Tan, Brian; Tang-Wai, David; Tartaglia, Maria C; Troyer, Angela K; Turnbull, John; Zinman, Lorne; Hegele, Robert A.
Afiliação
  • Dilliott AA; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Electronic address: adilliot@uwo.ca.
  • Sunderland KM; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
  • McLaughlin PM; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada; Nova Scotia Health Authority & Dalhousie University, Halifax, Nova Scotia, Canada.
  • Roberts AC; Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA; School of Communication Sciences and Disorders, Elborn College, Western University, London, Ontario, Canada.
  • Evans EC; Department of Medicine, University of Toronto, Mississauga, Ontario, Canada.
  • Abrahao A; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada.
  • Binns MA; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
  • Black SE; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; LCCampbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Research Program Sunnybrook Health Sciences Research Program, Sunnybrook Health Sciences Centre, Toronto, On
  • Borrie M; St. Joseph's Health Care Centre, London, Ontario, Canada; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Casaubon LK; Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; University Health Network Stroke Program, Toronto Western Hospital, Toronto, Ontario, Canada.
  • Dowlatshahi D; Nova Scotia Health Authority & Dalhousie University, Halifax, Nova Scotia, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Finger E; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada.
  • Fischer CE; Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Frank A; Nova Scotia Health Authority & Dalhousie University, Halifax, Nova Scotia, Canada; Bruyère Research Institute, Ottawa, Ontario, Canada.
  • Freedman M; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; Division of Neurology, Baycrest Health Sciences, Toronto, Ontario, Canada.
  • Grimes D; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Hassan A; Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada.
  • Jog M; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; London Health Sciences Centre, London, Ontario, Canada.
  • Kumar S; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Kwan D; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
  • Lang AE; Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.
  • Mandzia J; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Marras C; Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.
  • Masellis M; Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Cognitive & Movement Disorders Clinic and L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Science Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  • McIntyre AD; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Pasternak S; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Cognitive Neurology and Alzheimer's Disease Resear
  • Pollock BG; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Rajji TK; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
  • Robinson JF; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
  • Sahlas DJ; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Saposnik G; Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Clinical Outcomes and Decision Neuroscience Unit, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Sato C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
  • Seitz D; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Shoesmith C; London Health Sciences Centre, London, Ontario, Canada.
  • Steeves T; Division of Neurology, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Strother SC; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Swartz RH; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; LCCampbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Research Program Sunnybrook Health Sciences Research Program, Sunnybrook Health Sciences Centre, Toronto, On
  • Tan B; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
  • Tang-Wai D; Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada; University Health Network Memory Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.
  • Tartaglia MC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
  • Troyer AK; Department of Psychology, University of Toronto, Toronto, Ontario, Canada; Neuropsychology and Cognitive Health Program, Baycrest Health Sciences, Toronto, Ontario, Canada.
  • Turnbull J; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Zinman L; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada.
  • Hegele RA; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Neurobiol Aging ; 105: 378.e1-378.e9, 2021 09.
Article em En | MEDLINE | ID: mdl-34039480
For many years there has been uncertainty regarding how apolipoprotein E (APOE) E2 and E4 variants may influence overlapping features of neurodegeneration, such as cognitive impairment. We aimed to identify whether the APOE variants are associated with cognitive function across various neurodegenerative and cerebrovascular diagnoses (n = 513). Utilizing a comprehensive neuropsychology battery, multivariate multiple regression was used to assess the influence of APOE carrier status and disease cohort on performance across five cognitive domains. Irrespective of disease cohort, E4 carriers had significantly lower performance in verbal memory and visuospatial domains than those with E3/3, while E2 carriers' cognitive performance was not significantly different. However, E2 carriers with frontotemporal dementia (FTD) performed significantly worse than those with E3/3 in the attention/working memory, executive function, and visuospatial domains. Our results highlight that the influence of APOE variation on cognition is complex, in some cases varying based on diagnosis and possibly underlying disease pathology.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Cognição / Doenças Neurodegenerativas / Apolipoproteína E2 / Apolipoproteína E4 / Estudos de Associação Genética / Disfunção Cognitiva Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Cognição / Doenças Neurodegenerativas / Apolipoproteína E2 / Apolipoproteína E4 / Estudos de Associação Genética / Disfunção Cognitiva Idioma: En Ano de publicação: 2021 Tipo de documento: Article