Glia-derived temporal signals orchestrate neurogenesis in the Drosophila mushroom body.
Proc Natl Acad Sci U S A
; 118(23)2021 06 08.
Article
em En
| MEDLINE
| ID: mdl-34078666
ABSTRACT
Intrinsic mechanisms such as temporal series of transcription factors orchestrate neurogenesis from a limited number of neural progenitors in the brain. Extrinsic regulations, however, remain largely unexplored. Here we describe a two-step glia-derived signal that regulates neurogenesis in the Drosophila mushroom body (MB). In a temporal manner, glial-specific ubiquitin ligase dSmurf activates non-cell-autonomous Hedgehog signaling propagation by targeting the receptor Patched to suppress and promote the exit of MB neuroblast (NB) proliferation, thereby specifying the correct α/ß cell number without affecting differentiation. Independent of NB proliferation, dSmurf also stabilizes the expression of the cell-adhesion molecule Fasciclin II (FasII) via its WW domains and regulates FasII homophilic interaction between glia and MB axons to refine α/ß-lobe integrity. Our findings provide insights into how extrinsic glia-to-neuron communication coordinates with NB proliferation capacity to regulate MB neurogenesis; glial proteostasis is likely a generalized mechanism in orchestrating neurogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Comunicação Celular
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Neuroglia
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Corpos Pedunculados
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Proliferação de Células
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Neurogênese
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China