Total Synthesis of Aetokthonotoxin, the Cyanobacterial Neurotoxin Causing Vacuolar Myelinopathy.
Chemistry
; 27(47): 12032-12035, 2021 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-34081364
ABSTRACT
Aetokthonotoxin has recently been identified as the cyanobacterial neurotoxin causing Vacuolar Myelinopathy, a fatal neurologic disease, spreading through a trophic cascade and affecting birds of prey such as the bald eagle in the USA. Here, we describe the total synthesis of this specialized metabolite. The complex, highly brominated 1,2'-biindole could be synthesized via a Somei-type Michael reaction as key step. The optimised sequence yielded the natural product in five steps with an overall yield of 29 %.
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Base de dados:
MEDLINE
Assunto principal:
Doenças das Aves
/
Doenças do Sistema Nervoso Central
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Águias
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha