Pharmacokinetic Characteristics, Tissue Bioaccumulation and Toxicity Profiles of Oral Arsenic Trioxide in Rats: Implications for the Treatment and Risk Assessment of Acute Promyelocytic Leukemia.

Liu, Wensheng; Wang, Bin; Zhao, Yilei; Wu, Zhiqiang; Dong, Andi; Chen, Hongzhu; Lin, Liwang; Lu, Jing; Hai, Xin

Liu, Wensheng; Wang, Bin; Zhao, Yilei; Wu, Zhiqiang; Dong, Andi; Chen, Hongzhu; Lin, Liwang; Lu, Jing; Hai, Xin.

Afiliação

Liu W; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Wang B; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhao Y; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Wu Z; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Dong A; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Chen H; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Lin L; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Lu J; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hai X; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Front Pharmacol ; 12: 647687, 2021.

Article em En | MEDLINE | ID: mdl-34122070

Palavras-chave

acute promyelocytic leukemia; arsenic toxicity; dimethylated arsenic; monomethylated arsenic; oral arsenic trioxide; pharmacokinetics; tissue bioaccumulation

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China