NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages.
Science
; 372(6548): 1349-1353, 2021 06 18.
Article
em En
| MEDLINE
| ID: mdl-34140389
ABSTRACT
The epigenome of macrophages can be reprogrammed by extracellular cues, but the extent to which different stimuli achieve this is unclear. Nuclear factor κB (NF-κB) is a transcription factor that is activated by all pathogen-associated stimuli and can reprogram the epigenome by activating latent enhancers. However, we show that NF-κB does so only in response to a subset of stimuli. This stimulus specificity depends on the temporal dynamics of NF-κB activity, in particular whether it is oscillatory or non-oscillatory. Non-oscillatory NF-κB opens chromatin by sustained disruption of nucleosomal histone-DNA interactions, enabling activation of latent enhancers that modulate expression of immune response genes. Thus, temporal dynamics can determine a transcription factor's capacity to reprogram the epigenome in a stimulus-specific manner.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
/
Fator de Transcrição RelA
/
Epigenoma
/
Macrófagos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos