Early prediction of clinical response to anti-TNF treatment using multi-omics and machine learning in rheumatoid arthritis.

Yoosuf, Niyaz; Maciejewski, Mateusz; Ziemek, Daniel; Jelinsky, Scott A; Folkersen, Lasse; Müller, Malin; Sahlström, Peter; Vivar, Nancy; Catrina, Anca; Berg, Louise; Klareskog, Lars; Padyukov, Leonid; Brynedal, Boel

Yoosuf, Niyaz; Maciejewski, Mateusz; Ziemek, Daniel; Jelinsky, Scott A; Folkersen, Lasse; Müller, Malin; Sahlström, Peter; Vivar, Nancy; Catrina, Anca; Berg, Louise; Klareskog, Lars; Padyukov, Leonid; Brynedal, Boel.

Afiliação

Yoosuf N; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital.
Maciejewski M; Translational Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Ziemek D; Pfizer, Cambridge, MA, USA.
Jelinsky SA; Pfizer, Cambridge, MA, USA.
Folkersen L; Pfizer, Cambridge, MA, USA.
Müller M; Danish National Genome Center, Copenhagen, Denmark.
Sahlström P; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital.
Vivar N; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital.
Catrina A; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital.
Berg L; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital.
Klareskog L; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital.
Padyukov L; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital.
Brynedal B; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital.

Rheumatology (Oxford) ; 61(4): 1680-1689, 2022 04 11.

Article em En | MEDLINE | ID: mdl-34175943

Assuntos

Antirreumáticos; Artrite Reumatoide; Antirreumáticos/metabolismo; Antirreumáticos/uso terapêutico; Artrite Reumatoide/diagnóstico; Artrite Reumatoide/tratamento farmacológico; Artrite Reumatoide/genética; Biomarcadores; Feminino; Humanos; Leucócitos Mononucleares/metabolismo; Aprendizado de Máquina; Metotrexato/metabolismo; Metotrexato/uso terapêutico; Resultado do Tratamento; Inibidores do Fator de Necrose Tumoral/uso terapêutico; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

anti-TNF; inflammation; methotrexate; peripheral blood mononuclear cells; rheumatoid arthritis; treatment response

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Antirreumáticos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Antirreumáticos Idioma: En Ano de publicação: 2022 Tipo de documento: Article