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Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors.
Kim, Hanseul; Lipsyc-Sharf, Marla; Zong, Xiaoyu; Wang, Xiaoyan; Hur, Jinhee; Song, Mingyang; Wang, Molin; Smith-Warner, Stephanie A; Fuchs, Charles; Ogino, Shuji; Wu, Kana; Chan, Andrew T; Cao, Yin; Ng, Kimmie; Giovannucci, Edward L.
Afiliação
  • Kim H; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Lipsyc-Sharf M; Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
  • Zong X; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.
  • Wang X; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.
  • Hur J; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Song M; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Ma
  • Wang M; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical
  • Smith-Warner SA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Fuchs C; Yale Cancer Center, Smilow Cancer Hospital, New Haven, Connecticut.
  • Ogino S; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Cancer Immunology Program and Cancer Epidemiology
  • Wu K; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Chan AT; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Broad Institute of MIT and Ha
  • Cao Y; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Missouri; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; Division of Gastroenterology, Department of Medicine, Washington University School o
  • Ng K; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
  • Giovannucci EL; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical Sch
Gastroenterology ; 161(4): 1208-1217.e9, 2021 10.
Article em En | MEDLINE | ID: mdl-34245763
BACKGROUND & AIMS: Vitamin D has been implicated in colorectal cancer (CRC) pathogenesis, but it remains unknown whether total vitamin D intake is associated with early-onset CRC and precursors diagnosed before age 50. METHODS: We prospectively examined the association between total vitamin D intake and risks of early-onset CRC and precursors among women enrolled in the Nurses' Health Study II. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for early-onset CRC were estimated with Cox proportional hazards model. Multivariable-adjusted odds ratios (ORs) and 95% CIs for early-onset conventional adenoma and serrated polyp were estimated with logistic regression model. RESULTS: We documented 111 incident cases of early-onset CRC during 1,250,560 person-years of follow-up (1991 to 2015). Higher total vitamin D intake was significantly associated with a reduced risk of early-onset CRC (HR for ≥450 IU/day vs <300 IU/day, 0.49; 95% CI, 0.26-0.93; P for trend = .01). The HR per 400 IU/day increase was 0.46 (95% CI, 0.26-0.83). The inverse association was significant and appeared more evident for dietary sources of vitamin D (HR per 400 IU/day increase, 0.34; 95% CI, 0.15-0.79) than supplemental vitamin D (HR per 400 IU/day increase, 0.77; 95% CI, 0.37-1.62). For CRC precursors, the ORs per 400 IU/day increase were 0.76 (95% CI, 0.65-0.88) for conventional adenoma (n = 1,439) and 0.85 (95% CI, 0.75-0.97) for serrated polyp (n = 1,878). CONCLUSIONS: In a cohort of younger women, higher total vitamin D intake was associated with decreased risks of early-onset CRC and precursors.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Vitamina D / Vitaminas / Neoplasias Colorretais / Adenoma / Pólipos do Colo País/Região como assunto: America do norte Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Vitamina D / Vitaminas / Neoplasias Colorretais / Adenoma / Pólipos do Colo País/Região como assunto: America do norte Idioma: En Ano de publicação: 2021 Tipo de documento: Article