Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology.
Molecules
; 26(15)2021 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-34361735
ABSTRACT
Biofilms, the predominant growth mode of microorganisms, pose a significant risk to human health. The protective biofilm matrix, typically composed of exopolysaccharides, proteins, nucleic acids, and lipids, combined with biofilm-grown bacteria's heterogenous physiology, leads to enhanced fitness and tolerance to traditional methods for treatment. There is a need to identify biofilm inhibitors using diverse approaches and targeting different stages of biofilm formation. This review discusses discovery strategies that successfully identified a wide range of inhibitors and the processes used to characterize their inhibition mechanism and further improvement. Additionally, we examine the structure-activity relationship (SAR) for some of these inhibitors to optimize inhibitor activity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biofilmes
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Bibliotecas de Moléculas Pequenas
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Matriz Extracelular de Substâncias Poliméricas
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Bactérias Gram-Negativas
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Bactérias Gram-Positivas
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Antibacterianos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos