Non-invasive monitoring of saliva can be used to identify oxidative stress biomarkers in preterm and term newborn infants.
Acta Paediatr
; 110(12): 3255-3260, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34403512
ABSTRACT
AIM:
The aim of this study was to appraise the feasibility and reproducibility of applying a validated analytical method to determine salivary oxidative stress biomarkers in newborn infants.METHODS:
Prospective observational single-centre study was carried out in level III neonatal intensive care unit. Eligible patients were preterm infants and healthy full-term newborn infants. Salivary samples were analysed in the chromatographic system.RESULTS:
A total of 23 premature newborn infants and 13 full-term newborns were included. We analysed salivary levels of oxidative stress biomarkers for 5-F2t isoprostane, 15-E2t isoprostane, prostaglandin E2 and prostaglandin F2α. The multivariate predictive model showed a positive association between female and 5-F2t isoprostonae, and between female sex and prostglandin F2α. In addition, we found a positive association between gestational age and levels of prostaglandin E2 . Furthermore, in the premature group, we found a positive association between the inspired fraction of oxygen and levels of prostaglandin G2 .CONCLUSION:
We identified and determined lipid peroxidation biomarkers in term and preterm newborn infants' saliva using specific and validated mass spectrometry technology.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Saliva
/
Recém-Nascido Prematuro
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Espanha