Structural and Biochemical Features of Human Serum Albumin Essential for Eukaryotic Cell Culture.
Int J Mol Sci
; 22(16)2021 Aug 05.
Article
em En
| MEDLINE
| ID: mdl-34445120
ABSTRACT
Serum albumin physically interacts with fatty acids, small molecules, metal ions, and several other proteins. Binding with a plethora of bioactive substances makes it a critical transport molecule. Albumin also scavenges the reactive oxygen species that are harmful to cell survival. These properties make albumin an excellent choice to promote cell growth and maintain a variety of eukaryotic cells under in vitro culture environment. Furthermore, purified recombinant human serum albumin is mostly free from impurities and modifications, providing a perfect choice as an additive in cell and tissue culture media while avoiding any regulatory constraints. This review discusses key features of human serum albumin implicated in cell growth and survival under in vitro conditions.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Eucarióticas
/
Albumina Sérica Humana
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos