Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment.

Wang, Lei; Zhao, Lin; Gong, Fu-Lian; Sun, Chao; Du, Dan-Dan; Yang, Xiao-Xia; Guo, Xiu-Li

Wang, Lei; Zhao, Lin; Gong, Fu-Lian; Sun, Chao; Du, Dan-Dan; Yang, Xiao-Xia; Guo, Xiu-Li.

Afiliação

Wang L; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji-nan, 250012, China.
Zhao L; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji-nan, 250012, China.
Gong FL; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji-nan, 250012, China.
Sun C; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji-nan, 250012, China.
Du DD; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji-nan, 250012, China.
Yang XX; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji-nan, 250012, China.
Guo XL; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji-nan, 250012, China. guoxl@sdu.edu.cn.

Acta Pharmacol Sin ; 43(6): 1556-1567, 2022 Jun.

Article em En | MEDLINE | ID: mdl-34462562

Assuntos

Neoplasias da Mama; Macrófagos Associados a Tumor; Animais; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Feminino; Glucose; Humanos; Hipóxia/tratamento farmacológico; Hipóxia/metabolismo; Camundongos; Pectinas; Microambiente Tumoral

Palavras-chave

M2-like polarization; breast cancer; galectin-3 inhibitor; glucose transporter-1; modified citrus pectin; tumor hypoxic microenvironment; tumor-associated macrophages

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Macrófagos Associados a Tumor Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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