Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-ß pathway activation and neuroinflammation.

Liu, Xiumin; Chen, Wenhui; Wang, Chenkang; Liu, Weiwei; Hayashi, Toshihiko; Mizuno, Kazunori; Hattori, Shunji; Fujisaki, Hitomi; Ikejima, Takashi

Liu, Xiumin; Chen, Wenhui; Wang, Chenkang; Liu, Weiwei; Hayashi, Toshihiko; Mizuno, Kazunori; Hattori, Shunji; Fujisaki, Hitomi; Ikejima, Takashi.

Afiliação

Liu X; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China.
Chen W; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China.
Wang C; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China.
Liu W; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China.
Hayashi T; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China; Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1, Nakanomachi, Hachioji, Tokyo, 192-0015, Japan; Nippi Research Institute of Biomatrix, Toride, Ibara
Mizuno K; Nippi Research Institute of Biomatrix, Toride, Ibaraki 302-0017, Japan.
Hattori S; Nippi Research Institute of Biomatrix, Toride, Ibaraki 302-0017, Japan.
Fujisaki H; Nippi Research Institute of Biomatrix, Toride, Ibaraki 302-0017, Japan.
Ikejima T; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning, China. Electronic address: ikejimat@vip.sina.com.

Physiol Behav ; 241: 113593, 2021 11 01.

Article em En | MEDLINE | ID: mdl-34536434

Assuntos

Fármacos Neuroprotetores; Doença de Parkinson; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina; Animais; Ansiedade/tratamento farmacológico; Ansiedade/etiologia; Depressão/tratamento farmacológico; Depressão/etiologia; Modelos Animais de Doenças; Humanos; Fator Regulador 3 de Interferon; Camundongos; Camundongos Endogâmicos C57BL; Doença de Parkinson/complicações; Doença de Parkinson/tratamento farmacológico; Qualidade de Vida; Silibina

Palavras-chave

Depression/anxiety behavior; Neuroinflammation; Parkinson's disease; STING-pathway; Silibinin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Fármacos Neuroprotetores Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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