A modular strategy for the synthesis of marine originated meroterpenoid-type natural products.
Org Biomol Chem
; 19(43): 9439-9447, 2021 11 10.
Article
em En
| MEDLINE
| ID: mdl-34679152
ABSTRACT
A modular strategy for meroterpenoid-type marine natural products has been developed from commercially available (+)-sclareolide using a palladium-catalyzed tandem carbene migratory insertion as one of the key steps. Its applicability is showcased by the formal synthesis of (-)-pelorol and 9-epi-pelorol and the concise total synthesis of (+)-yahazunone and (+)-yahazunol. It is worth noting that the formal synthesis of (-)-pelorol and 9-epi-pelorol was achieved by controlling the reaction sequence of hydrogenation and cyclization.
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1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article