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Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
Hopkins, Brian T; Bame, Eris; Bajrami, Bekim; Black, Cheryl; Bohnert, Tonika; Boiselle, Carrie; Burdette, Doug; Burns, Jeremy C; Delva, Luisette; Donaldson, Douglas; Grater, Richard; Gu, Chungang; Hoemberger, Marc; Johnson, Josh; Kapadnis, Sudarshan; King, Kris; Lulla, Mukesh; Ma, Bin; Marx, Isaac; Magee, Tom; Meissner, Robert; Metrick, Claire M; Mingueneau, Michael; Murugan, Paramasivam; Otipoby, Kevin L; Polack, Evelyne; Poreci, Urjana; Prince, Robin; Roach, Allie M; Rowbottom, Chris; Santoro, Joseph C; Schroeder, Patricia; Tang, Hao; Tien, Eric; Zhang, Fengmei; Lyssikatos, Joseph.
Afiliação
  • Hopkins BT; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Bame E; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Bajrami B; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Black C; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Bohnert T; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Boiselle C; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Burdette D; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Burns JC; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Delva L; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Donaldson D; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Grater R; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Gu C; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Hoemberger M; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Johnson J; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Kapadnis S; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • King K; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Lulla M; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Ma B; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Marx I; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Magee T; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Meissner R; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Metrick CM; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Mingueneau M; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Murugan P; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Otipoby KL; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Polack E; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Poreci U; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Prince R; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Roach AM; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Rowbottom C; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Santoro JC; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Schroeder P; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Tang H; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Tien E; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Zhang F; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
  • Lyssikatos J; Research & Development, Biogen, Cambridge, Massachusetts 02142, United States.
J Med Chem ; 65(2): 1206-1224, 2022 01 27.
Article em En | MEDLINE | ID: mdl-34734694
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Descoberta de Drogas / Tirosina Quinase da Agamaglobulinemia / Esclerose Múltipla Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Descoberta de Drogas / Tirosina Quinase da Agamaglobulinemia / Esclerose Múltipla Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos