Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic.

Huizing, Lennart R S; Ellis, Shane R; Beulen, Bart W A M M; Barré, Florian P Y; Kwant, Paul B; Vreeken, Rob J; Heeren, Ron M A

Huizing, Lennart R S; Ellis, Shane R; Beulen, Bart W A M M; Barré, Florian P Y; Kwant, Paul B; Vreeken, Rob J; Heeren, Ron M A.

Afiliação

Huizing LRS; The Maastricht MultiModal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Ellis SR; The Maastricht MultiModal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Beulen BWAMM; Instrument Development Engineering and Evaluation, Engineering Department, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Barré FPY; The Maastricht MultiModal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Kwant PB; Instrument Development Engineering and Evaluation, Engineering Department, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Vreeken RJ; The Maastricht MultiModal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Heeren RMA; Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.

Clin Mass Spectrom ; 12: 7-15, 2019 Apr.

Article em En | MEDLINE | ID: mdl-34841074

Palavras-chave

CHCl3, chloroform; DHB, 2 5-dihydroxybenzoic acid; Da, Dalton; FT-ICR, Fourier transform ion cyclotron resonance; FT-MS, Fourier transform mass spectrometry; FWHM, full width at half maximum; H&E, hematoxylin and eosin; ITO, indium tin oxide; MALDI, matrix assisted laser desorption ionization; MSI, mass spectrometry imaging; MeOH, methanol; NRM, norharmane; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; Pa, Pascal; Ppm, parts per million; RSD, relative standard deviation; S/N, signal-to-noise ratio; SM, sphingomyelin; TFA, trifluoroacetic acid; TIC, total ion count; TOF, time-of-flight; V:V, volume concentration; e.g, exempli gratia; i.e, id es; m/z, mass over charge ratio; mBar, milliBar

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda